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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 420-429 doi: 10.1007/s11684-016-0478-3

Abstract: expression of CDKN2C induced a cell cycle arrest at the G0/G1 phase and a partial differentiationthis study highlights the importance of CDKN2C inactivation in the abnormal cell cycle progression and differentiationblock of APL cells and may provide new insights into the study of pathogenesis and targeted therapy

Keywords： CDKN2C     acute promyelocytic leukemia     cell cycle arrest     differentiation    

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Stem cell research in hepatocellular carcinoma

SUN Chengyi, ZUO Shi

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 1-4 doi: 10.1007/s11684-008-0001-6

Abstract: However, whether HCC is resulted from the differentiation block of stem cells and, moreover, which liver

Keywords： lineage     hepato-pancreas     differentiation block     carcinogenesis     current status    

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Monocyte subsets and their differentiation tendency after burn injury

Guangqing Wang, Zhaofan Xia

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 397-400 doi: 10.1007/s11684-013-0298-7

Abstract:

Monocytes are critical effectors and regulators of immune response. Studying the nomenclature of monocyte subsets may be beneficial for understanding the complex function of monocytes in steady and inflammatory states. A monocyte has the potential to differentiate into dendritic cells or macrophages, and this behavior significantly changes in severely burned patients and mice. The findings in the present study may help enhance understanding on the perturbation of the immune system after severe burn injury.

Keywords： monocyte     differentiation     burn    

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: Brain development requires a delicate balance between self-renewal and differentiation in neural stemYet, the regulation of TET2 in the process of neuronal differentiation remains unknown.Here, the protein level of TET2 was reduced by the ubiquitin-proteasome pathway during NSC differentiationThe protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiationillustrated that the GID complex negatively regulates TET2 protein stability, further modulates NSC differentiation

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

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Laser ablation of block copolymers with hydrogen-bonded azobenzene derivatives

Jintang Huang, Youju Huang, Si Wu

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 450-456 doi: 10.1007/s11705-018-1735-6

Abstract: fabricated by hydrogen-bonding azobenzene derivatives (AzoR) to poly(4-vinyl pyridine) blocks of polystyrene-block-poly

Keywords： laser ablation     block copolymers     hydrogen-bond     azobenzene derivatives     supramolecular assembly    

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Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 416-428 doi: 10.1007/s11684-021-0838-5

Abstract: in the progression of megakaryopoiesis, we speculate that abivertinib can affect megakaryocyte (MK) differentiationwith abivertinib and observed megakaryopoiesis to determine the biological effect of abivertinib on MK differentiationimpaired the CFU-MK formation, proliferation of CD34+ HSC-derived MK progenitor cells, and differentiationand functions of MKs and inhibited Meg-01-derived MK differentiation.Thus, these preclinical data collectively suggested that abivertinib could inhibit MK differentiation

Keywords： abivertinib     Btk inhibitor     platelet     megakaryocyte     megakaryopoiesis     thrombopoiesis    

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The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of

Shixin ZHANG,Shaohua WU,Weimin TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 357-362 doi: 10.15302/J-FASE-2016125

Abstract: Although jasmonates have been demonstrated to be crucial in the regulation of secondary laticifer differentiation, the mechanism for the jasmonate-induced secondary laticifer differentiation remains to be elucidatedthat trichostatin A (TSA), an inhibitor of histone deacetylation, could induce the secondary laticifer differentiationThe results suggest that histone acetylation is essential for the secondary laticifer differentiation

Keywords： Hevea brasiliensis     histone acetylation     laticifer differentiation     trichostatin     vascular cambia    

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Tank-dependence of the functionality and network differentiation of activated sludge community in a full-scale

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1636-x

Abstract:

● Environmental parameters affected functional bacteria and network associations.

Keywords： Activated sludge     Bacterial community     Tank-dependence     Network association     Functional bacteria    

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Ductility improvement of GFRP-RC beams using precast confined concrete block in compression zone

Frontiers of Structural and Civil Engineering doi: 10.1007/s11709-023-0968-8

Abstract: ductility of their compression zones, the present study proposes using a precast confined concrete block

Keywords： ductility     four-point bending test     glass fiber-reinforced polymer     precast confined concrete block    

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coupling relationship of industrial agglomeration and low-carbon economy considering spatiotemporal differentiation

Frontiers of Engineering Management 2023, Volume 10, Issue 2,   Pages 285-299 doi: 10.1007/s42524-022-0197-1

Abstract: Although China’s construction machinery thrives to meet the needs of construction, a number of challenges still remain to be overcome, such as lack of thorough knowledge of regional disparities and several limitations in terms of carbon emissions and economic development. Meanwhile, a low-carbon economy was proposed and implemented in China. This research aims to investigate the differences in industrial agglomeration of construction machineries and further explore the relationship between industrial agglomeration and low-carbon economy. On this basis, spatiotemporal analysis was performed to evaluate the levels of industrial agglomeration in different regions based on the situations of China’s construction machinery industry. Furthermore, this study explored the interaction between industrial agglomeration and low-carbon economy utilizing the coupling coordination analysis method. Results showed that the coupling coordination of the two subsystems was extremely unbalanced in 2006, and it maintained an increasing trend, reaching a relatively high level in 2018. Finally, suggestions, such as establishing a policy guarantee system and implementing variable policies in different regions, were proposed to provide guidelines for the government decision-making and promote the sustainable development of China’s construction machinery industry.

Keywords： spatiotemporal differentiation     industrial agglomeration     low-carbon economy     construction machinery    

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Preparation of polysulfone-based block copolymer ultrafiltration membranes by selective swelling and

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 745-754 doi: 10.1007/s11705-021-2038-x

Abstract: Selective swelling of block copolymers of polysulfone-b-poly(ethylene glycol) is an emerging strategySelective swelling was performed on the obtained block copolymer structures in the solvent pair of ethanolhydrochloric acid and the spaces initially occupied by CaCO3 provided extra pores to the block

Keywords： block copolymers     selective swelling     ultrafiltration     CaCO3 nanoparticles     sacrificial nanofillers    

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Thermoresponsive block copolymer supported Pt nanocatalysts for base-free aerobic oxidation of 5-hydroxymethyl

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1514-1523 doi: 10.1007/s11705-021-2092-4

Abstract: a thermoresponsive poly(acrylamide-co-acrylonitrile)-b-poly(N-vinylimidazole) blockThe imidazole groups in the block copolymer were conducive to the improvement of catalytic performance

Keywords： aerobic oxidation     base-free     5-hydroxymethyl-2-furfural     Pt nanoparticle     thermoresponsive block copolymer    

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Molecular dynamics study of water diffusion in an amphiphilic block copolymer with large difference in

Yang Zhou, Phillip Choi

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 440-447 doi: 10.1007/s11705-017-1626-2

Abstract: Isothermal-isobaric molecular dynamics simulation was used to study the diffusion mechanism of water in polyurethane- -poly( -isopropyl acrylamide) (PU- -PNIPAm) with a hydrophobic PU/hydrophilic PNIPAm mass ratio of 1.4 to 1 at 298 K and 450 K. Here, the experimental glass transition temperature ( ) of PU is 243 K while that of PNIPAm is 383 K. Different amounts of water up to 15 wt-% were added to PU- -PNIPAm. We were able to reproduce the specific volumes and glass transition temperatures (250 K and 390 K) of PU- -PNIPAm. The computed self-diffusion coefficient of water increased exponentially with increasing water concentration at both temperatures (i.e., following the free volume model of Fujita). It suggested that water diffusion in PU- -PNIPAm depends only on its fractional free volume despite the free volume inhomogeneity. It is noted that at 298 K, PU is rubbery while PNIPAm is glassy. Regardless of temperature, radial distribution functions showed that water formed clusters with sizes in the range of 0.2–0.4 nm in PU- -PNIPAm. At low water concentrations, more clusters were found in the PU domain but at high water concentrations, more in the PNIPAm domain. It is believed that water molecules diffuse as clusters rather than as individual molecules.

Keywords： molecular dynamics simulation     amphiphilic block copolymer     free volume     water diffusivity     fujita model    

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Wear mechanism of disc-brake block material for new type of drilling rig

WANG Xinhua, WANG Simin, ZHANG Siwei, WANG Deguo

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 1,   Pages 10-16 doi: 10.1007/s11465-008-0009-2

Abstract: Topography and elementary components of the brake block’s wear surface are analyzed by employing SEMWhen the frictional temperature is lower, the surface film of the brake block is thinner, dense, smoothwear, the hard peaks from the friction surface of the disc-brake plough on the surface of the brake blockfriction heat, obvious softening and plastic flow can be found on the friction surface of the brake blockThermal decomposition of cohesive material in the brake block is simultaneously strengthened, so that

Keywords： asbestos-free frictional     Fracture     cyclization     friction     disc-brake    

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Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesisTherefore, investigating the mechanism of neural differentiation and AHN is of great importance for developingHowever, whether CBD can modulate rNSC differentiation and hippocampal neurogenesis is unknown.administration of CBD rescued depressive-like symptoms in CRS mice and prevented rNSCs overactivation and differentiationThese results revealed a previously unknown neural mechanism for neural differentiation and AHN in depression

Keywords： cannabidiol     depression     radial neural stem cells     neurogenesis    

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Title Author Date Type Operation

Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Journal Article

Stem cell research in hepatocellular carcinoma

SUN Chengyi, ZUO Shi

Journal Article

Monocyte subsets and their differentiation tendency after burn injury

Guangqing Wang, Zhaofan Xia

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Laser ablation of block copolymers with hydrogen-bonded azobenzene derivatives

Jintang Huang, Youju Huang, Si Wu

Journal Article

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Journal Article

The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of

Shixin ZHANG,Shaohua WU,Weimin TIAN

Journal Article

Tank-dependence of the functionality and network differentiation of activated sludge community in a full-scale

Journal Article

Ductility improvement of GFRP-RC beams using precast confined concrete block in compression zone

Journal Article

coupling relationship of industrial agglomeration and low-carbon economy considering spatiotemporal differentiation

Journal Article

Preparation of polysulfone-based block copolymer ultrafiltration membranes by selective swelling and

Journal Article

Thermoresponsive block copolymer supported Pt nanocatalysts for base-free aerobic oxidation of 5-hydroxymethyl

Journal Article

Molecular dynamics study of water diffusion in an amphiphilic block copolymer with large difference in

Yang Zhou, Phillip Choi

Journal Article

Wear mechanism of disc-brake block material for new type of drilling rig

WANG Xinhua, WANG Simin, ZHANG Siwei, WANG Deguo

Journal Article

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Journal Article